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Urgh, medical reporting is almost as bad as Tech reporting. No critical thinking.

this is the gist: "There is a new drug that acts similarly to ibuprofen, but appears to be less aggressive towards kidneys. Equally as bad for the heart."

However 70% of the participants failed to complete the study, so its not long term. No percentage risks are quoted. It also doesn't compare how effective celecoxib is compared to the much cheaper and well understood(interaction wise) ibuprofen.

It also notes that high doses were not tested: "600mg ibuprofen three times a day"

That my friend is a fucking large dose, as in three weeks and you have an ulcer dose.



Actually, that isn't that large of a dose.

The normal tablest in the US are 200mg: Lots of folks take 2 a few times a day: 400mg 3 times a day, as recommended on most of the packaging.

Prescription ibuprofen is 800mg tablets (most times). This is a fairly common dosage, 3-4 times a day.


Sorry good point. I was thinking about over the counter. My fault

600mg four times a day is inline with the BNF daily limit of 2.4g: http://www.evidence.nhs.uk/formulary/bnf/current/10-musculos...

Seriously the BNF is a brilliant resource, it has this to say about celecoxib: http://www.evidence.nhs.uk/formulary/bnf/current/10-musculos...


Really?! Is this among the elderly who already have lots of little aches here and there or the general population? When I broke my arm I took 400mg about six or seven times over three days and for a cold I tend to take one or two paracetamol, but taking pain killers regularly sounds very absurd to me and I don’t know of anyone who takes anything stronger than coffee regularly and more than once a month.


Everything is in general: I might have worked in a pharmacy, but I'm not a pharmacist or a doctor.

But I know a lot of folks will take ibuprofen for 7-10 days at those rates. It is pretty common, and just as common for people to regularly take naproxen a few times a day for chronic pain.

Taking pain killers regularly sounds absurd to you because you don't have that sort of chronic pain. And pain is a funny thing: My mother openly admitted that she would get to a point with migraines where the pain was so bad, the side effects didn't quite seem to matter (She learned to go to the hospital or doctor before then).

More often, however, these pain killers are the very things that makes every day life bearable. Some people it means they can be more active but others it just means they can open doors and grab toilet paper with less pain.

Your method is great for people that have occasional pain or needs: After all, it seems a bit silly to take it for no actual reason. And as far as the folks you know, well, if you are young that is more likely. And if not, it is just something the people you know don't talk about.


thats the difference between acute (short term) and chronic (long term)

In acute cases paracetamol can have an 8 gram daily limit. long term you're going to see problems.

When you have something like arthritis, or and old joint injury, you'll be needing long term anti inflammatories


Do you know anyone with long term chronic pain?


All of the participants in the study had pre-existing heart problems as well.




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