Apologies for being mind-numbingly obvious, but this is an opportunity for being very disruptive, and similar opportunities exist in every hide-bound industry. Unfortunately you cant do it on a ramen or even a YC budget. However if you work for a feisty player and can convince them that there is money to be made in selling their back office software, you have a chance. A few years ago I almost pulled it off until the principals realized the cost of HN grade sr developers.

And most of you wont be in a position to do so, because you avoid these industries like the plague. :-)