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if the substance has good water solubility, you can do this by dilution, measuring volume, without a scale.

sertraline for instance: https://pubchem.ncbi.nlm.nih.gov/compound/68617#section=Solu...

don't do this with medications with special coatings or other methods for controlling release (SR/XR/etc).



Using distilled water would be a good idea as well.




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