You can just ask ChatGPT these questions these days, but it was a fun read:
fly.io depends on Firecracker microVMs, so you should be concerned if you're running untrusted code, but not concerned about other people interacting with you wrt v8.
Cloudflare depends on v8 isolates, which depend on the trustworthiness of the v8 sandbox, which is a non-trivial hurdle, but not an insurmountable one for attackers with the resources to have a v8 bug in the first place.
fly.io depends on Firecracker microVMs, so you should be concerned if you're running untrusted code, but not concerned about other people interacting with you wrt v8.
Cloudflare depends on v8 isolates, which depend on the trustworthiness of the v8 sandbox, which is a non-trivial hurdle, but not an insurmountable one for attackers with the resources to have a v8 bug in the first place.