"C16G2 works very rapidly in vitro with a unique membrane-active mechanism of action. This physical method of killing is not targeting a single gene product, and therefore single gene mutations are unlikely to confer resistance. Also, mechanism of action, route of administration and clearance of the drug are expected to limit drug exposure to the oral mucosa, so no impact on the development of resistance in other bacteria is expected, in contrast to concerns about overuse of traditional antibiotics. Despite believing resistance is not likely, we will carefully monitor resistance in clinical trials and in laboratory experiments."
"C16G2 works very rapidly in vitro with a unique membrane-active mechanism of action. This physical method of killing is not targeting a single gene product, and therefore single gene mutations are unlikely to confer resistance. Also, mechanism of action, route of administration and clearance of the drug are expected to limit drug exposure to the oral mucosa, so no impact on the development of resistance in other bacteria is expected, in contrast to concerns about overuse of traditional antibiotics. Despite believing resistance is not likely, we will carefully monitor resistance in clinical trials and in laboratory experiments."
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